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Association between chronic periodontitis and the risk of Alzheimer’s disease: combination of text mining and GEO dataset by Zhengye Jiang; Yanxi Shi; Wenpeng Zhao; Liwei Zhou; Bingchang Zhang; Yuanyuan Xie; Yaya Zhang; Guowei Tan; Zhanxiang Wang is a Dentistry article available to read on EtoBox.
What is Association between chronic periodontitis and the risk of Alzheimer’s disease: combination of text mining and GEO dataset about?
## Abstract ## Background Although chronic periodontitis has previously been reported to be linked with Alzheimer's disease (AD), the pathogenesis between the two is unclear. The purpose of this study is to analyze and screen the relevant and promising molecular markers between chronic periodontitis and Alzheimer's disease (AD). ## Methods In this paper, we analyzed three AD expression datasets and extracted differentially expressed genes (DEGs), then intersected them with chronic periodontitis genes obtained from text mining, and finally obtained integrated DEGs. We followed that by enriching the matching the matching cell signal cascade through DAVID analysis. Moreover, the MCODE of Cytoscape software was employed to uncover the protein–protein interaction (PPI) network and the matching hub gene. Finally, we verified our data using a different independent AD cohort. ## Results The chronic periodontitis gene set acquired from text abstracting was intersected with the previously obtained three AD groups, and 12 common genes were obtained. Functional enrichment assessment uncovered 12 cross-genes, which were mainly linked to cell morphogenesis involved in neuron differentiation, lea
Who reads Association between chronic periodontitis and the risk of Alzheimer’s disease: combination of text mining and GEO dataset?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- Zhengye Jiang; Yanxi Shi; Wenpeng Zhao; Liwei Zhou; Bingchang Zhang; Yuanyuan Xie; Yaya Zhang; Guowei Tan; Zhanxiang Wang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Dentistry (Health Sciences)