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Can I read Spontaneous Repopulation of β-Catenin Null Livers with β-Catenin-positive Hepatocytes After Chronic Murine Liver Injury on EtoBox?
Spontaneous Repopulation of β-Catenin Null Livers with β-Catenin-positive Hepatocytes After Chronic Murine Liver Injury by Michael D. Thompson; Emily D. Wickline; William B. Bowen; Amy Lu; Sucha Singh; Amalea Misse; Satdarshan P.S. Monga is a Medicine article available to read on EtoBox.
What is Spontaneous Repopulation of β-Catenin Null Livers with β-Catenin-positive Hepatocytes After Chronic Murine Liver Injury about?
Prolonged exposure of mice to diet containing 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) results in hepatobiliary injury, atypical ductular proliferation, oval cell appearance, and limited fibrosis. Previously, we reported that short-term ingestion of DDC diet by hepatocyte-specific β-catenin conditional knockout (KO) mice led to fewer A6-positive oval cells than wildtype (WT) littermates. To examine the role of β-catenin in chronic hepatic injury and repair, we exposed WT and KO mice to DDC for 80 and 150 days. Paradoxically, long-term DDC exposure led to significantly more A6-positive cells, indicating greater atypical ductular proliferation in KO, which coincided with increased fibrosis and cholestasis. Surprisingly, at 80 and 150 days in KO we observed a significant amelioration of hepatocyte injury. This coincided with extensive repopulation of β-catenin null livers with β-catenin-positive hepatocytes at 150 days, which was preceded by appearance of β-catenin-positive hepatocyte clusters at 80 days and a few β-catenin-positive hepatocytes at earlier times. Intriguingly, occasional β-catenin-positive hepatocytes that were negative for progenitor markers were also obse
Who reads Spontaneous Repopulation of β-Catenin Null Livers with β-Catenin-positive Hepatocytes After Chronic Murine Liver Injury?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Michael D. Thompson; Emily D. Wickline; William B. Bowen; Amy Lu; Sucha Singh; Amalea Misse; Satdarshan P.S. Monga
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)