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Cullin 3 Regulates STAT3 in Colitis by Guozhong Jiang is a document available to read on EtoBox.
What is Cullin 3 Regulates STAT3 in Colitis about?
This study investigates the role of myeloid-derived cullin 3 (CUL3) in regulating STAT3 phosphorylation and its implications for intestinal inflammation. The authors demonstrate that CUL3 down-regulates O-GlcNAc transferase (OGT) expression, which inhibits STAT3 O-GlcNAcylation, leading to enhanced STAT3 activation and IL-10 production in macrophages. The findings suggest that CUL3 is crucial for modulating immune responses and may influence the severity of colonic inflammation and tumorigenesis.
- Author
- Guozhong Jiang
- Language
- EN