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Evaluation of a methacrylate‐bonded cyclodextrins as a monolithic chiral stationary phase for capillary electrochromatography (CEC)‐UV and CEC coupled to mass spectrometry by Congying Gu; Shahab A. Shamsi is a Engineering article available to read on EtoBox.
What is Evaluation of a methacrylate‐bonded cyclodextrins as a monolithic chiral stationary phase for capillary electrochromatography (CEC)‐UV and CEC coupled to mass spectrometry about?
## Abstract Glycidyl methacrylate‐bonded β‐cyclodextrin (GMA‐β‐CD) is synthesized as a new chiral monomer by direct chemical bonding with GMA using a fast and simple alternative procedure. Next, rigid and homogenous monolithic columns were prepared by polymerization of GMA‐β‐CD monomer with ethylene dimethacrylate (EDMA), in the presence of commonly used porogens and a charged achiral monomer to form a versatile chiral monolith. This is the first report in which a preparation procedure for a methacrylate‐bonded CD is introduced for chiral separations in CEC. The degree of substitution of GMA‐β‐CD monomer and mobile‐phase parameters were optimized to achieve the highest enantioselectivity and plate number. To evaluate the GMA‐β‐CD monolithic column, different classes of chiral compounds were screened. Under the optimized β‐CD monolith phase and the optimum mobile‐phase conditions, 30 neutral and basic chiral compounds and two acidic compounds could be separated. The high chemical and mechanical stability, homogenous microflow and no loss of material at the interface allows for the first time the feasibility of applying this polymer‐based monolithic column for CEC coupled to ESI‐MS.
Who reads Evaluation of a methacrylate‐bonded cyclodextrins as a monolithic chiral stationary phase for capillary electrochromatography (CEC)‐UV and CEC coupled to mass spectrometry?
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- Author
- Congying Gu; Shahab A. Shamsi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0173-0835)
- Published
- 2011
- Language
- EN
- Field
- Engineering (Physical Sciences)