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CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential by Gabriele De Simone; Emilia M. C. Mazza; Antonino Cassotta; Alexey N. Davydov; Mirela Kuka; Veronica Zanon; Federica De Paoli; Eloise Scamardella; Maria Metsger; Alessandra Roberto; Karolina Pilipow; Federico S. Colombo; Elena Tenedini; Enrico Tagliafico; Luca Gattinoni; Domenico Mavilio; Clelia Peano; David A. Price; Satya P. Singh; Joshua M. Farber; Valentina Serra; Francesco Cucca; Francesco Ferrari; Valeria Orrù; Edoardo Fiorillo; Matteo Iannacone; Dmitriy M. Chudakov; Federica Sallusto; Enrico Lugli is a Immunology and Microbiology article available to read on EtoBox.
What is CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential about?
Abstract In mice, the ability of naive T (TN) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8+ TN cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3+ TN cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide–HLA class I Ags. Moreover, CXCR3+ TN cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3+ TN cells were transcriptionally equivalent to murine CXCR3+ TN cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8+ T cells.
Who reads CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Gabriele De Simone; Emilia M. C. Mazza; Antonino Cassotta; Alexey N. Davydov; Mirela Kuka; Veronica Zanon; Federica De Paoli; Eloise Scamardella; Maria Metsger; Alessandra Roberto; Karolina Pilipow; Federico S. Colombo; Elena Tenedini; Enrico Tagliafico; Luca Gattinoni; Domenico Mavilio; Clelia Peano; David A. Price; Satya P. Singh; Joshua M. Farber; Valentina Serra; Francesco Cucca; Francesco Ferrari; Valeria Orrù; Edoardo Fiorillo; Matteo Iannacone; Dmitriy M. Chudakov; Federica Sallusto; Enrico Lugli
- Publisher
- The American Association of Immunologists
- Published
- 2019
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)