About this Biochemistry, Genetics and Molecular Biology article
Agents for the Treatment of Gout: Current Advances and Future Perspectives by Xiaoyi Zeng; Yajing Liu; Yuxin Fan; Di Wu; Yangyang Meng; Mingze Qin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
Gout is characterized by hyperuricemia and the deposition of monosodium urate (MSU) crystals around joints. Despite the availability of several drugs on the market, its treatment remains challenging owing to the notable side effects, such as hepatorenal toxicity and cardiovascular complications, that are associated with most existing agents. This perspective aims to summarize the current research progress in the development of antigout agents, particularly focusing on xanthine oxidase (XO) and urate anion transporter 1 (URAT1) inhibitors from a medicinal chemistry viewpoint and their preliminary structureactivity relationships (SARs). This perspective provides valuable insights and theoretical guidance to medicinal chemists for the discovery of antigout agents with novel chemical structures, better efficiency, and lower toxicity. ## ■ SIGNIFICANCE • The current progress in the research of antigout agents is summarized in this perspective. • The design strategies, structure-activity relationships, and molecular docking studies for XO and URAT1 inhibitors are discussed in detail from a medicinal chemistry viewpoint. • Potential strategies for developing antigout agents are introduced
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xiaoyi Zeng; Yajing Liu; Yuxin Fan; Di Wu; Yangyang Meng; Mingze Qin
- Publisher
- American Chemical Society (ACS)
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)