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Neural Tube Formation in the Mouse: a Morphometric and Computerized Three-dimensional Reconstruction Study of the Relationship Between Apical Constriction of Neuroepithelial Cells and the Shape of the Neuroepithelium by Kevin T. Bush; Francis J. Lynch; Albert S. DeNittis; Alan B. Steinberg; Hsin-yi Lee; Robert G. Nagele is a Neuroscience article available to read on EtoBox.

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Morphometry and computerized three-dimensional reconstruction were used to study the relationship between apical constriction of neuroepithelial cells and the pattern of bending of the neuroepithelium in the developing neural tube of the 12-somite mouse embryo. The neuroepithelium of the mouse exhibits prominent regional variations in size and shape along the embryo axis. The complex shape of most of the cephalic neural tube (e.g., forebrain and midbrain) is due to the coexistence of concave and convex bending sites whereas more caudal regions (e.g., hindbrain and spinal cord) generally lack sites of convex bending and have a relatively simple shape. The apical morphology of neuroepithelial cells was found to be correlated more closely with the local status of bending of the neuroepithclium than with the specific region of the neural tube in which they are located. In areas of enhanced apical constriction, microfilament bundles were particularly prominent. Morphometry revealed that patterns of bending of the neuroepithelium were correlated almost exactly with those of apical constriction throughout the forming neural tube. These findings support the idea that apical constriction of

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Author

Kevin T. Bush; Francis J. Lynch; Albert S. DeNittis; Alan B. Steinberg; Hsin-yi Lee; Robert G. Nagele

Publisher

Springer; Springer-Verlag; Springer Verlag; J.F. Bergmann; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-2061)

Published

1990

Language

EN

Field

Neuroscience (Life Sciences)