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Dunn et al. discuss the distinctions and implications of classifying phase 3 trials as superiority or non-inferiority, particularly in non-regulatory contexts. They argue that this classification is often arbitrary and can hinder clear scientific communication, emphasizing the need for guidelines to align more closely with clinical and public health objectives. The authors advocate for a more flexible approach to trial design and analysis that prioritizes estimation over rigid adherence to statistical frame

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myemailforsmlebrainapp1

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EN