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Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy by Alberto Domingo López-Muñoz; Jefferson J. S. Santos; Jonathan W. Yewdell is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy about?

## Significance Despite the unprecedented global response to the COVID-19 pandemic, critical aspects of HCoV pathogenesis remain unclear, including mechanisms underlying immune evasion and viral manipulation of the cytokine network. The nucleocapsid (N) protein is the most abundant HCoV translation product. N induces strong antibody and T cell responses. Cell surface SARS-CoV-2 N modulates innate and adaptive immunity. In this article, we expand those findings to the common cold HCoV-OC43. We show that cell surface HCoV N plays conserved roles in pathogenesis as a chemokine modulator, and it is a target for antibody-based immunity. As a much more conserved target for antibodies than Spike, N is potentially an important target for future vaccines that induce antigenic drift resistant immunity.

Who reads Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy?

Author

Alberto Domingo López-Muñoz; Jefferson J. S. Santos; Jonathan W. Yewdell

Publisher

Proceedings of the National Academy of Sciences

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)