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Is a diagnosis of infiltrating versus in Situ ductal carcinoma of the breast possible in fine-needle aspiration specimens? by Hyung Ju C. Shin; Nour Sneige is a Medicine article available to read on EtoBox.

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With widespread use of mammographic screening, more cases of ductal carcinoma in situ (DCIS) are being detected. Fine-needle aspiration (FNA) is an established and reliable method for diagnosing breast carcinoma. However, its usefulness in distinguishing infiltrating ductal carcinoma (IDC) from DCIS is controversial. ## METHODS. The authors retrospectively reviewed 36 breast FNAs (23 palpable lesions and 13 nonpalpable lesions) that were confirmed histologically as being exclusively DCIS. On review, 27 cases (75%) were categorized as carcinomas, and 9 cases (25%) were categorized as proliferative lesions with atypia. Findings of only these 27 carcinomas were compared with findings of 42 breast FNAs that surgically were proven to be IDC (Ն 85% invasive). Five key cytologic features compared included the presence of fibroadipose tissue, stromal fragments, benign epithelial groups, angulated tumor cell clusters, and tubular structures of tumor cells; for the first three features, the proximity with tumor cells also was noted. ## RESULTS. The presence of stromal fragments associated with tumor cells was significantly different between cases of DCIS (9 of 27; 33%) and IDC (29 of 42; 69%

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Author

Hyung Ju C. Shin; Nour Sneige

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1998

Language

EN

Field

Medicine (Health Sciences)