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Can I read Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways on EtoBox?
Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways by Christoph T. Ellebrecht; Damian Maseda; Aimee S. Payne is a Medicine article available to read on EtoBox.
What is Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways about?
Pemphigus and pemphigoid are paradigms for understanding the mechanisms of antibody-mediated autoimmune disease in humans. In pemphigus, IgG4predominant autoantibodies cause intraepidermal blistering by direct interference with desmoglein interactions and subsequent disruption of desmosomes and signaling pathways. In pemphigoid, IgG1, IgG4, and IgE autoantibodies against basement membrane zone antigens directly interfere with hemidesmosomal adhesion, activating complement and Fc receptormediated effector pathways. Unraveling disease mechanisms in pemphigus and pemphigoid has identified numerous opportunities for clinical trials, which hold promise to identify safer and more effective therapies for these potentially life-threatening diseases.
Who reads Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Christoph T. Ellebrecht; Damian Maseda; Aimee S. Payne
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)
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