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Albumin adsorption onto pyrolytic carbon: A molecular mechanics approach by Sara Mantero; Daniela Piuri; Franco M. Montevecchi; Simone Vesentini; Fabio Ganazzoli; Giuseppina Raffaini is a Medicine article available to read on EtoBox.

What is Albumin adsorption onto pyrolytic carbon: A molecular mechanics approach about?

## Abstract A number of implants of cardiac valve prosthesis, vascular prosthesis, and coronary stents present a pyrolytic carbon interface to blood. Plasma protein adsorption is essential for the hemocompatibility of the implanted devices. This work quantitatively evaluates the molecular interaction force between a biomaterial surface (pyrolytic carbon) and plasma protein (albumin) binding sites through a simplified molecular model of the interface consisting of (i) multioriented graphite microcrystallites; (ii) selected fragments of albumin; and (iii) a water environment. A number of simplifying assumptions were made in the calculation: the albumin molecule was divided into hydrophobic and hydrophilic subunits (helices); an idealized clean, nonoxidized polycrystalline graphite surface was assumed to approximate the surface of pyrolytic carbon. The interaction forces between albumin helices and pyrolytic carbon surfaces are evaluated from potential energy data. These forces are decomposed into a normal and a tangential component. The first one is calculated using a docking procedure (__F__~⊥tot MAX~ = 4.16 × 10^−20^ N). The second one (F~__‖__~), calculated by mean of geometric mo

Who reads Albumin adsorption onto pyrolytic carbon: A molecular mechanics approach?

Author

Sara Mantero; Daniela Piuri; Franco M. Montevecchi; Simone Vesentini; Fabio Ganazzoli; Giuseppina Raffaini

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2001

Language

EN

Field

Medicine (Health Sciences)