Opening book details…
Can I read MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients on EtoBox?
MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients by Takuya Niimoto; Tomoyuki Nakasa; Masakazu Ishikawa; Atsushi Okuhara; Bunichiro Izumi; Masataka Deie; Osami Suzuki; Nobuo Adachi; Mitsuo Ochi is a Medicine article available to read on EtoBox.
What is MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients about?
## Abstract ## Background Interleukin (IL)-17 is an important factor in rheumatoid arthritis (RA) pathogenesis. MicroRNA (miRNA)s are a family of non coding RNAs and associated with human diseases including RA. The purpose of this study is to identify the miRNAs in the differentiation of IL-17 producing cells, and analyze their expression pattern in the peripheral blood mononuclear cells (PBMC) and synovium from RA patients. ## Methods IL-17 producing cells were expanded from CD4+T cell. MiRNA microarray was performed to identify the miRNAs in the differentiation of IL-17 producing cells. Quantitative polymerase chain reaction was performed to examine the expression patterns of the identified miRNAs in the PBMC and synovium from RA and osteoarthritis (OA) patients. Double staining combining __in situ__ hybridization and immunohistochemistry of IL-17 was performed to analyze the expression pattern of identified miRNA in the synovium. ## Results Six miRNAs, let-7a, miR-26, miR-146a/b, miR-150, and miR-155 were significantly up regulated in the IL-17 producing T cells. The expression of miR-146a and IL-17 was higher than in PBMC in the patients with low score of Larsen grade and short
Who reads MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Takuya Niimoto; Tomoyuki Nakasa; Masakazu Ishikawa; Atsushi Okuhara; Bunichiro Izumi; Masataka Deie; Osami Suzuki; Nobuo Adachi; Mitsuo Ochi
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2474)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)