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Anti-inflammatory activity of the lipophilic metabolites from Scolymus hispanicus L by Kandil, Zeinab A.; Esmat, Ahmed; El-Din, Reham Salah; Ezzat, Shahira M. is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Anti-inflammatory activity of the lipophilic metabolites from Scolymus hispanicus L about?

The golden thistle, Scolymus hispanicus L. (Asteraceae), is a prickly perennial herb that is widely grown in Mediterranean and in Southeastern Europe. The aim of current study was to isolate and identify the constituents of S. hispanicus L. chloroform fraction, and assess their anti-inflammatory activity in-vitro. Chemical investigation led to isolation of one new guaianolide sesquiterpene; namely iso-japonicolactone (4), three tritepenes namely lupeol acetate (1), lupeol (2), and oleanolic acid (5), and the sterol stigmasterol (3). The isolated compounds demonstrated free radical scavenging activity against DPPH with compound 4 being able to scavenge more than 90% of DPPH radical at 100 mM. Treatment of the peripheral blood mononuclear cells (PBMC) stimulated with phytohaemagglutinin (PHA) with the isolated compounds resulted in a decrease in nuclear factor kappa (NFkB) p65 content in a dose-dependent manner. Compound 4 was the most efficient in decreasing NFkB p65 at the lowest concentration (1 mM), followed by compound 5. In addition, cell treatment with isolated compounds resulted in doserelated reduction of interleukins (IL-6 and IL-1b), and tumor necrosis factor (TNF-a). To t

Who reads Anti-inflammatory activity of the lipophilic metabolites from Scolymus hispanicus L?

Author

Kandil, Zeinab A.; Esmat, Ahmed; El-Din, Reham Salah; Ezzat, Shahira M.

Publisher

Africa Journals Online; Elsevier ; Elsevier BV (ISSN 1727-9321)

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)