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LncRNA CRNDE is downregulated and associated with poor prognostic markers in chronic lymphocytic leukemia by Amira M. F. Shehata; Suzy F. Gohar; Nashwa M. Muharram; Shaimaa Sherif Soliman; Hadeel M. Shalaby; Samar M. Kamal Eldin; Fathia I. EL‐Bassal is a Medicine article available to read on EtoBox.

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## Abstract ## Introduction Chronic lymphocytic leukemia (CLL) is characterized by a very heterogeneous clinical outcome. Thus, a plethora of prognostic factors and systems has been identified to place patients into different risk categories and to guide therapy decisions. The classic clinical staging models by Rai and Binet have been the cornerstone of patient management for several years. The greater insight into the molecular biology of CLL facilitated the advent of prognostic genetic biomarkers that are expected to impact clinical practice soon in the future. Therefore, we aimed to investigate the expression of long non‐coding RNA (lncRNA) CRNDE in patients with CLL, and to analyze its relationship with the clinicopathological parameters of CLL. ## Methods In this study, 40 untreated CLL patients and 30 age‐ and gender‐matched controls were enrolled. The analysis of lncRNA CRNDE expression was determined using reverse transcription‐quantitative polymerase chain reaction technique. ## Results Our result confirmed the downregulated expression of LncRNA CRNDE in CLL patients compared to controls (__p__ < 0.001). The low expression of CRNDE was significantly associated with poor pr

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Author

Amira M. F. Shehata; Suzy F. Gohar; Nashwa M. Muharram; Shaimaa Sherif Soliman; Hadeel M. Shalaby; Samar M. Kamal Eldin; Fathia I. EL‐Bassal

Publisher

Wiley

Published

2023

Field

Medicine (Health Sciences)