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LncRNA LINC00240 suppresses invasion and migration in non-small cell lung cancer by sponging miR-7-5p by Ku, Gwan Woo ;Kang, Yujin ;Yu, Seong-Lan ;Park, Joonghoon ;Park, Sejin ;Jeong, In Beom ;Kang, Min Woong ;Son, Ji Woong ;Kang, Jaeku is a Medicine article available to read on EtoBox.

What is LncRNA LINC00240 suppresses invasion and migration in non-small cell lung cancer by sponging miR-7-5p about?

## Abstract ## Background lncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of lncRNAs and microRNA in cancer progression. In previous studies, miR-7-5p has been found to be significantly down-regulated in mesenchymal-like lung cancer cell lines and directly regulated EGFR. In this work, we investigated the lncRNA partner of miR-7-5p in the progression of lung cancer. ## Methods We investigated the expression of miR-7-5p and the lncRNA after transfection with an miR-7-5p mimics using a microarray. The microarray results were validated using quantitative real time-polymerase Chain Reaction (qRT-PCR). The regulatory effects of lncRNA on miR-7-5p and its target were evaluated by changes in the expression of miR-7-5p after transfection with siRNAs for lncRNA and the synthesis of full-length lncRNA. The effect of miR-7-5p on lncRNA and the miRNA target was evaluated after transfection with miRNA mimic and inhibitor. The role of lncRNA in cancer progression was determined using invasion and migration assays. The level of lncRNA and EGFR in lung cancer and normal lung tissue was analyzed using TCGA data. ## Re

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Author

Ku, Gwan Woo ;Kang, Yujin ;Yu, Seong-Lan ;Park, Joonghoon ;Park, Sejin ;Jeong, In Beom ;Kang, Min Woong ;Son, Ji Woong ;Kang, Jaeku

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)