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Ameliorative role of bioactive phytoconstituents targeting obesity associated NAFLD by modulation of inflammation and lipogenesis pathways: a comprehensive review by Pervej Alom Barbhuiya; Saikat Sen; Manash Pratim Pathak is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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By 2025, the projected global obesity rates for both men and women are 18% and 21%, respectively. Obesity raises the risk of several comorbidities like cardiovascular disease, gastrointestinal disorders, type 2 diabetes, respiratory problems, and most importantly non-alcoholic fatty liver disease (NAFLD). NAFLD is commonly considered to be both a consequence and a contributor to metabolic dysfunctions such as obesity, given the liver's pivotal role in metabolism. NAFLD is a range of disease phenotypes that initiate hepatocyte inflammation and lipid accumulation owing to de novo lipogenesis (DNL). NAFLD has the potential to advance to nonalcoholic steatohepatitis, marked by hepatic fibrosis and the subsequent emergence of NAFLD-associated cirrhosis and hepatocellular carcinoma. Several notable biomarkers, including C-reactive protein, tumour necrosis factor-a, interleukin-6, leptin, fatty acid synthase and sterol regulatory element binding protein-1c have been found to have a direct correlation with inflammation and DNL. Several research studies have provided evidence regarding the effectiveness and safety of plant derived bioactive compounds plants for managing obesity associated N
Who reads Ameliorative role of bioactive phytoconstituents targeting obesity associated NAFLD by modulation of inflammation and lipogenesis pathways: a comprehensive review?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Pervej Alom Barbhuiya; Saikat Sen; Manash Pratim Pathak
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)