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Colocalization of calbindin D-28k, calretinin, and GABA immunoreactivities in neurons of the human temporal cortex by del Ro, Mara R.; DeFelipe, Javier is a Neuroscience article available to read on EtoBox.

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The calcium-binding proteins calbindin D-28k (CalB) and calretinin (CalR) have been shown to be useful markers of neuronal subpopulations located mainly in layers 11-111 of the neocortex of a variety of species, including human. Double labeling immunocytochemical studies of CalB, CalR, and GABA in experimental animals have shown that CalB and CalR are present in separate subpopulations of neurons. However, there are no studies of colocalization of these calcium-binding proteins and GABA in the human neocortex. The principal goal of the present work was to investigate the degree of colocalization of these substances in layers 11-111 of the human temporal neocortex, using a postembedding immunocytochemical method. The patterns of staining for CalB, CalR, and GABA in the human cortex were similar to those found in monkey neocortex. However, the degree of colocalization for certain combinations was different from that reported in the monkey and other experimental animals. A relatively large proportion of CalB-and CalR-immunoreactive cells (approximately 71% and 7496, respectively) were found to be immunoreactive for GABA. However, the degree of colocalization of CalB with CalR was low

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Author

del Ro, Mara R.; DeFelipe, Javier

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)