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A Nonlinear Reduced-Order Model of the Corpus Callosum Under Planar Coronal Excitation by Alireza Mojahed; Javid Abderezaei; Mehmet Kurt; Lawrence A. Bergman; Alexander F. Vakakis is a Medicine article available to read on EtoBox.

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## Abstract Traumatic brain injury (TBI) is often associated with microstructural tissue damage in the brain, which results from its complex biomechanical behavior. Recent studies have shown that the deep white matter (WM) region of the human brain is susceptible to being damaged due to strain localization in that region. Motivated by these studies, in this paper, we propose a geometrically nonlinear dynamical reduced order model (ROM) to model and study the dynamics of the deep WM region of the human brain under coronal excitation. In this model, the brain hemispheres were modeled as lumped masses connected via viscoelastic links, resembling the geometry of the corpus callosum (CC). Employing system identification techniques, we determined the unknown parameters of the ROM, and ensured the accuracy of the ROM by comparing its response against the response of an advanced finite element (FE) model. Next, utilizing modal analysis techniques, we determined the energy distribution among the governing modes of vibration of the ROM and concluded that the demonstrated nonlinear behavior of the FE model might be predominantly due to the special geometry of the brain deep WM region. Further

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Author

Alireza Mojahed; Javid Abderezaei; Mehmet Kurt; Lawrence A. Bergman; Alexander F. Vakakis

Publisher

ASME International

Published

2020

Language

EN

Field

Medicine (Health Sciences)