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Can I read Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole on EtoBox?
Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole by Wallace T. Ashton; Rosemary M. Sisco; Hong Dong; Kathryn A. Lyons; Huaibing He; George A. Doss; Barbara Leiting; Reshma A. Patel; Joseph K. Wu; Frank Marsilio; Nancy A. Thornberry; Ann E. Weber is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole about?
A series of b-aminoacylpiperidines bearing various fused five-membered heterocyclic rings was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective inhibition could be obtained, depending on choice of heterocycle, regioisomerism, and substitution. In particular, one analog (74, DPP-IV IC 50 = 26 nM) exhibited good oral bioavailability and acceptable half-life in the rat, albeit with rather high clearance.
Who reads Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wallace T. Ashton; Rosemary M. Sisco; Hong Dong; Kathryn A. Lyons; Huaibing He; George A. Doss; Barbara Leiting; Reshma A. Patel; Joseph K. Wu; Frank Marsilio; Nancy A. Thornberry; Ann E. Weber
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)