Can I read Elevated Double Negative T Cells in Pediatric Autoimmunity on EtoBox?

Elevated Double Negative T Cells in Pediatric Autoimmunity by James A. Tarbox; Molly P. Keppel; Nermina Topcagic; Charles Mackin; Miriam Ben Abdallah; Kevin W. Baszis; Andrew J. White; Anthony R. French; Megan A. Cooper is a Immunology and Microbiology article available to read on EtoBox.

What is Elevated Double Negative T Cells in Pediatric Autoimmunity about?

## Purpose: Autoimmune diseases are thought to be caused by a loss of self-tolerance of the immune system. one candidate marker of immune dysregulation in autoimmune disease is the presence of increased double negative t cells (dnts) in the periphery. dnts are characteristically elevated in autoimmune lymphoproliferative syndrome, a systemic autoimmune disease caused by defective lymphocyte apoptosis due to fas pathway defects. dnts have also been found in the peripheral blood of adult patients with systemic lupus erythematosus (sle), where they may be pathogenic. dnts in children with autoimmune disease have not been investigated. ## Methods: We evaluated dnts in pediatric patients with sle, mixed connective tissue disease (mctd), juvenile idiopathic arthritis (jia), or elevated antinuclear antibody (ana) but no systemic disease. dnts (cd3(+)cd56(-)tcrαβ(+)cd4(-)cd8(-)) from peripheral blood mononuclear cells were analyzed by flow cytometry from 54 pediatric patients including: 23 sle, 15 jia, 11 ana and 5 mctd compared to 28 healthy controls. ## Results: Sixteen cases (29.6 %) had elevated dnts (≥2.5 % of cd3(+)cd56(-)tcrαβ(+) cells) compared to 1 (3.6 %) control. medication usag

Who reads Elevated Double Negative T Cells in Pediatric Autoimmunity?

Author

James A. Tarbox; Molly P. Keppel; Nermina Topcagic; Charles Mackin; Miriam Ben Abdallah; Kevin W. Baszis; Andrew J. White; Anthony R. French; Megan A. Cooper

Publisher

Springer Science and Business Media LLC

Published

2014

Language

EN

Field

Immunology and Microbiology (Life Sciences)