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Phosphorylated 4E‐binding protein 1 (p‐4E‐BP1): a novel prognostic marker in human astrocytomas by Penelope Korkolopoulou; Georgia Levidou; Elias A El‐Habr; Christina Piperi; Christos Adamopoulos; Vassilis Samaras; Efstathios Boviatsis; Irene Thymara; Eleni‐Andriana Trigka; Stratigoula Sakellariou; Nikolaos Kavantzas; Efstratios Patsouris; Angelica A Saetta is a Medicine article available to read on EtoBox.
What is Phosphorylated 4E‐binding protein 1 (p‐4E‐BP1): a novel prognostic marker in human astrocytomas about?
Korkolopoulou P, Levidou G, El‐Habr E A, Piperi C, Adamopoulos C, Samaras V, Boviatsis E, Thymara I, Trigka E‐A, Sakellariou S, Kavantzas N, Patsouris E & Saetta A A (2012) __Histopathology__ **61,** 293–305 **Phosphorylated 4E‐binding protein 1 (p‐4E‐BP1): a novel prognostic marker in human astrocytomas** **Aims:** To investigate the significance of the mammalian target of rapamycin (mTOR) pathway in astrocytic tumours, published information in this context being limited, especially regarding phosphorylated 4E‐binding protein (p‐4E‐BP) 1. **Methods and results:** Paraffin‐embedded tissue from 111 patients with astroglial tumours (grades II–IV) was investigated for the association of phosphorylated mTOR (p‐mTOR) signalling components with phosphorylated extracellular signal‐related kinase 1/2 (p‐ERK1/2) and phosphorylated AKT (p‐AKT) expression, clinicopathological features, angiogenesis, isocitrate dehydrogenase 1 (IDH1)‐R132H, and survival. Expression was also quantified by western blot analysis in 12 cases and in three primary glioma cell cultures following rapamycin treatment. p‐mTOR expression correlated with p‐4E‐BP1 expression and marginally with p‐p70S6K expression. p‐4E‐B
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- Author
- Penelope Korkolopoulou; Georgia Levidou; Elias A El‐Habr; Christina Piperi; Christos Adamopoulos; Vassilis Samaras; Efstathios Boviatsis; Irene Thymara; Eleni‐Andriana Trigka; Stratigoula Sakellariou; Nikolaos Kavantzas; Efstratios Patsouris; Angelica A Saetta
- Publisher
- Wiley
- Published
- 2012
- Language
- EN
- Field
- Medicine (Health Sciences)