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Thermal Lens Detection Device by Kazuma Mawatari; Toshinori Ohashi; Tomohiko Ebata; Manabu Tokeshi; Takehiko Kitamori is a Engineering article available to read on EtoBox.

What is Thermal Lens Detection Device about?

A thermal lens detection device was developed to realize an easy-to-use, portable and sensitive detector for nonfluorescent molecules. Two laser diodes (658 nm for excitation and 785 nm for probe) were made coaxial in an optical unit and were coupled to a single-mode optical fiber. On a microfluidic chip, a small holder for the optical fiber was fixed, and micro-lenses (numerical aperture of 0.2) were also integrated inside the holder. The micro-lenses were designed to realize an adequate chromatic aberration (50 μm), which was essential for sensitive thermal lens detection. Compared with conventional thermal lens detection systems which required very laborious and accurate optical alignment with the microchannel, the new device needed just attachment-detachment of the optical fiber, which was important for practical application. The lower limit of detection was 10 nM for nickel(II) phthalocyaninetetrasulfonic acid tetrasodium salt solutions (model sample), and the absorbance was 9 × 10(-6) AU. The absolute number of molecules detected was less than 200 zmol. The coefficient of variance for 5-time attachment-detachment of the optical probe was as small as 3.6%. The technical develo

Who reads Thermal Lens Detection Device?

Author

Kazuma Mawatari; Toshinori Ohashi; Tomohiko Ebata; Manabu Tokeshi; Takehiko Kitamori

Publisher

Royal Society of Chemistry (RSC)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)