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What is SETD2 Methyltransferase Role in Cancer about?

SETD2 is a lysine methyltransferase that plays a crucial role in cancer by trimethylating histone H3 at lysine 36 (H3K36me3), which is important for various cellular processes including transcription and DNA repair. Recent findings also highlight its non-histone methylation activities, particularly on cytoskeletal proteins like tubulin and actin, affecting cell migration and cytoskeleton dynamics. The review discusses the structural and functional aspects of SETD2, its mutations in cancers, and its dual rol

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