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Regionalization of pIgR expression in the mucosa of mouse small intestine by Aldo A. Reséndiz-Albor; Humberto Reina-Garfias; Saúl Rojas-Hernández; Adriana Jarillo-Luna; Víctor Rivera-Aguilar; Angel Miliar-García; Rafael Campos-Rodríguez is a Immunology and Microbiology article available to read on EtoBox.
What is Regionalization of pIgR expression in the mucosa of mouse small intestine about?
Few reports exist on the differences in cell populations or immunological functions between the proximal and distal segments of the small intestine (SI). In the current contribution we analyzed the expression of the polymeric immunoglobulin receptor (pIgR) and alpha chains as well as the density of IgA-producing cells from the proximal and distal intestinal segments from Balb/c mice. Furthermore, by using real-time RT-PCR we quantified the expression of cytokines (TNF-alpha, IFN-gamma, IL-4 and TGF-beta), Toll-like receptor-4 (TLR-4), and the glucocorticoid receptor (GR) involved in pIgR expression in intestinal epithelial cells (IEC). In this study, for the first time it has been demonstrated that the expression of the pIgR as well as alpha chain was greater in the proximal than the distal segment of the small intestine of normal mice. Moreover, we found striking differences in the expression of cytokines at the different intestinal compartments. Whereas the expression of TNF-alpha, IFN-gamma and TGF-beta was higher in lamina propria lymphocytes (LPL) of the distal than proximal segment, it was higher in IEC of the proximal than distal segment. In contrast, the expression of the g
Who reads Regionalization of pIgR expression in the mucosa of mouse small intestine?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Aldo A. Reséndiz-Albor; Humberto Reina-Garfias; Saúl Rojas-Hernández; Adriana Jarillo-Luna; Víctor Rivera-Aguilar; Angel Miliar-García; Rafael Campos-Rodríguez
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)
- Published
- 2010
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)