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Long-term air pollution and risk of amyotrophic lateral sclerosis mortality in the Women's Health Initiative cohort by Angela M. Malek; Vincent C. Arena; Ruopu Song; Eric A. Whitsel; Judith R. Rager; James Stewart; Jeff D. Yanosky; Duanping Liao; Evelyn O. Talbott is a Environmental Science article available to read on EtoBox.

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## Background: Amyotrophic lateral sclerosis (als) is a neurodegenerative disorder with no cure. although the etiology of sporadic als is largely unknown, environmental exposures may affect als risk. ## Objective: We investigated relationships between exposure to long-term ambient particulate matter (pm) and gaseous air pollution (ap) and als mortality. ## Methods: Within the women's health initiative (whi) cohort of 161,808 postmenopausal women aged 50-79 years at baseline (1993-1998), we performed a nested case-control study of 256 als deaths and 2486 matched controls with emphasis on pm constituents (pm, pm, and coarse pm [pm-]) and gaseous pollutants (no, no, so, and ozone). time-varying ap exposures estimates were averaged 5, 7.5, and 10 years prior to als death using both a gis-based spatiotemporal generalized additive mixed model and ordinary kriging (empirical and multiple imputation, mi). conditional logistic regression was used to estimate the relative risk of als death. ## Results: In general, pm and pm-related risks were not significantly elevated using either method. however, for pm, odds ratios (ors) were >1.0 for both methods at all time periods using mi and empirica

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Author

Angela M. Malek; Vincent C. Arena; Ruopu Song; Eric A. Whitsel; Judith R. Rager; James Stewart; Jeff D. Yanosky; Duanping Liao; Evelyn O. Talbott

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)