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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus by Jessica E. Malberg; Amelia J. Eisch; Eric J. Nestler; Ronald S. Duman is a Neuroscience article available to read on EtoBox.

What is Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus about?

Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study was to investigate the effect of antidepressants on hippocampal neurogenesis in the adult rat, using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells. Our studies demonstrate that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus. Administration of several different classes of antidepressant, but not non-antidepressant, agents was found to increase BrdU-labeled cell number, indicating that this is a common and selective action of antidepressants. In addition, upregulation of the number of BrdU-labeled cells is observed after chronic, but not acute, treatment, consistent with the time course for the therapeutic action of antidepressants. Additional studies demonstrated that antidepressant treatment increases the proliferation of hippocampal cells and that these new cells mature and become neurons, as determined by triple labeling for BrdU and neuronal- or glial-specific markers. These findings raise the possibil

Who reads Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus?

Author

Jessica E. Malberg; Amelia J. Eisch; Eric J. Nestler; Ronald S. Duman

Publisher

Society for Neuroscience

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)