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Can I read Nanomedicine from amphiphilized prodrugs: Concept and clinical translation on EtoBox?
Nanomedicine from amphiphilized prodrugs: Concept and clinical translation by Jiajia Xiang; Xin Liu; Guiping Yuan; Runnan Zhang; Quan Zhou; Tao Xie; Youqing Shen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Nanomedicine from amphiphilized prodrugs: Concept and clinical translation about?
Nanomedicines generally consisting of carrier materials with small fractions of active pharmaceutical ingredients (API) have long been used to improve the pharmacokinetics and biodistributions, augment the therapeutic efficacies and mitigate the side effects. Amphiphilizing hydrophobic/hydrophilic drugs to prodrugs capable of self-assembly into well-defined nanostructures has emerged as a facile approach to fabricating nanomedicines because this amphiphilized prodrug (APD) strategy presents many advantages, including minimized use of inert carrier materials, well-characterized prodrug structures, fixed and high drug loading contents, 100% loading efficiency, and burst-free but controlled drug release. This review comprehensively summarizes recent advances in APDs and their nanomedicines, from the rationale and the stimuli-responsive linker chemistry for on-demand drug release to their progress to the clinics, clinical performance of APDs, as well as the challenges and perspective on future development.
Who reads Nanomedicine from amphiphilized prodrugs: Concept and clinical translation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jiajia Xiang; Xin Liu; Guiping Yuan; Runnan Zhang; Quan Zhou; Tao Xie; Youqing Shen
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)