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A Review of Auraptene as an Anticancer Agent by Zahra Tayarani-Najaran; Nilufar Tayarani-Najaran; Samira Eghbali is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Review of Auraptene as an Anticancer Agent about?

Auraptene is a bioactive monoterpene coumarin isolated from __Citrus aurantium__ and __Aegle marmelos__ that belong to the Rutaceae family. Auraptene can modulate intracellular signaling pathways that control cell growth, inflammation and apoptosis and can exert pharmacological properties such as anti-bacterial, anti-fungal, antileishmania and anti-oxidant activity. Auraptene had inhibitory and chemo-preventive effects on the proliferation, tumorigenesis and growth of several cancer cell lines through increase in the activity of glutathione S-transferase, formation of DNA adducts and reduction of the number of aberrant crypt foci. Auraptene exhibits anticancer effects via targeting different cell signaling pathways such as cytokines, genes modulating cellular proliferation, growth factors, transcription factors and apoptosis. The present review is a detailed survey of scientific researches on the cytotoxicity and anticancer activity of Auraptene on cancer cells and tumor bearing animals.

Who reads A Review of Auraptene as an Anticancer Agent?

Author

Zahra Tayarani-Najaran; Nilufar Tayarani-Najaran; Samira Eghbali

Publisher

Frontiers Media SA

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)