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Molecular Mechanisms Controlling Mucosal Humoral Responses in Human by J. Fayette; B. Dubois; S. Vandenabeele; C. Barthélémy; C. Caux; J. Banchereau; F. Brière is a Immunology and Microbiology article available to read on EtoBox.

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Introductton: To study the effect of ultraviolet B (UVB) radiation on human epidermal Langerhans cells (LC). normal human skin was irradiated ex viw with single doses of UVB. Matertals and mods: LG that spontaneously migrated from epidermal sheets during overnight culture were used to assess possible effects of UVB on the T-cell stimulator-y function. Full-thickness skin biopsies were used to study alterations in migratory properties. Reeultcl: UVB exposure of epidermal sheets caused a reduction of the percentage of HlA-DR positive cells migrating from the sheets, as well as an impaired capacity to induce proliferation of allogeneic T cells, when compared to cells migrating from nonexposed control sheets. When a correction was made for the decreased number of HLA-DR positive LC migrating from the irradiated epidermis, however, it appeared that on a per cell basis the T-cell stimulatory capacity was identical for LC migrating from UVB-exposed and nonexposed epidermis. UVB-induced thyminedimers could be demonstrated in the LC from UVB-treated skin. The presence of this DNA damage indicates that the LC had received significant doses of UVB. As concerned the migratory properties of LC,

Who reads Molecular Mechanisms Controlling Mucosal Humoral Responses in Human?

Author

J. Fayette; B. Dubois; S. Vandenabeele; C. Barthélémy; C. Caux; J. Banchereau; F. Brière

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)

Published

1997

Field

Immunology and Microbiology (Life Sciences)