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Soluble E-selectin and soluble ICAM-1 levels as markers of the activity of atopic dermatitis in children by Albert Wolkerstorfer; Huub F. J. Savelkoul; Flora B. De Waard van der Spek; Herman J. Neijens; Tim van Meurs; Arnold P. Oranje is a Medicine article available to read on EtoBox.

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The expression of adhesion molecules is up‐regulated in the skin of atopic dermatitis (AD) patients, and the levels of the soluble adhesion molecules sE‐selectin and sICAM‐1 have been reported to reflect the endothelial activation in the skin of AD patients. The objective of the study was to investigate the relationship between symptom score and levels of sE‐selectin, sICAM‐1 and sVCAM‐1 before and after 2 weeks of treatment. Eighteen children with an exacerbation of AD were admitted and treated with corticosteroid dilutions under occlusive wet dressings (wet‐wrap treatment). Symptom score (objective SCORAD) and levels of sE‐selectin, sICAM‐1, and sVCAM‐1 were assessed before and after 2 weeks of treatment. A significant correlation between the objective SCORAD before treatment and the level of sE‐selectin (p < 0.05), but not the level of sICAM‐1 (p = 0.7) or sVCAM‐1 (p = 0.5) was observed. The treatment resulted in a high degree of remission, which was reflected by a significant decrease in the level of sICAM‐1 (p < 0.01), whereas there was only a trend in the level of sE‐selectin to decrease (p = 0.08). The level of sE‐selectin after 2 weeks of treatment still correlated signific

Who reads Soluble E-selectin and soluble ICAM-1 levels as markers of the activity of atopic dermatitis in children?

Author

Albert Wolkerstorfer; Huub F. J. Savelkoul; Flora B. De Waard van der Spek; Herman J. Neijens; Tim van Meurs; Arnold P. Oranje

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0905-6157)

Published

2003

Language

EN

Field

Medicine (Health Sciences)