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Can I read Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system on EtoBox?
Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system by Morale, MC; Gallo, F; Tirolo, C; Testa, N; Caniglia, S; Marletta, N; SpinaâPurrello, V; Avola, R; Caucci, F; Tomasi, P; Delitala, G; Barden, N; Marchetti, B is a Immunology and Microbiology article available to read on EtoBox.
What is Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system about?
Bidirectional communication between the neuroendocrine and immune systems during ontogeny plays a pivotal role in programming the development of neuroendocrine and immune responses in adult life. Signals generated by the hypothalamic–pituitary–gonadal axis (i.e. luteinizing hormone‐releasing hormone, LHRH, and sex steroids), and by the hypothalamic–pituitary–adrenocortical axis (glucocorticoids (GC)), are major players coordinating the development of immune system function. Conversely, products generated by immune system activation exert a powerful and long‐lasting regulation on neuroendocrine axes activity. The neuroendocrine–immune system is very sensitive to preperinatal experiences, including hormonal manipulations and immune challenges, which may influence the future predisposition to several disease entities. We review our work on the ongoing mutual regulation of neuroendocrine and immune cell activities, both at a cellular and molecular level. In the central nervous system, one chief compartment is represented by the astroglial cell and its mediators. Hence, neuron–glial signalling cascades dictate major changes in response to hormonal manipulations and pro‐inflammatory trig
Who reads Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Morale, MC; Gallo, F; Tirolo, C; Testa, N; Caniglia, S; Marletta, N; SpinaâPurrello, V; Avola, R; Caucci, F; Tomasi, P; Delitala, G; Barden, N; Marchetti, B
- Publisher
- Nature Publishing Group; Wiley (Blackwell Publishing); John Wiley and Sons Inc.; Wiley (ISSN 0818-9641)
- Published
- 2001
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)