Can I read Heterogeneity of Familial Risk in Sarcoidosis on EtoBox?

Heterogeneity of Familial Risk in Sarcoidosis by Benjamin A. Rybicki; Doug Harrington; Marcie Major; Michael Simoff; John Popovich Jr.; Mary Maliarik; Michael C. Iannuzzi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Heterogeneity of Familial Risk in Sarcoidosis about?

Familial clustering of sarcoidosis and the higher prevalence and clinical severity of sarcoidosis in African Americans suggests etiologic heterogeneity. To test for heterogeneity in familial risk of sarcoidosis, we studied 3,395 siblings and parents of 558 index cases (361 African American, 197 Caucasian) diagnosed at Henry Ford Hospital between 1951 and 1994. Using the age-and sex-specific cumulative incidence of sarcoidosis in our sample, we found a statistically significant heterogeneity in familial risk of disease (P < ,001). To determine if this was due to a greater risk of sarcoidosis in African Americans, we recalculated disease probabilities using age-, sex-, and race-specific disease cumulative incidence and found the same amount of heterogeneity in familial risk ( P < ,001). Index cases ( n = 69) from high-risk families were more likely to be African American (odds ratio [OR] = 3.24; 95% confidence interval (CI) = 1.71-6.14) and to have an offspring or second-degree relative affected (OR = 6.21; 95% CI = 2.86-13.45). We conclude that the heterogeneity of familial sarcoidosis risk found in this study is supportive of multiple etiologies. Our results also show that a quanti

Who reads Heterogeneity of Familial Risk in Sarcoidosis?

Author

Benjamin A. Rybicki; Doug Harrington; Marcie Major; Michael Simoff; John Popovich Jr.; Mary Maliarik; Michael C. Iannuzzi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)