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Identification of Genes Potentially Involved in the Acquisition of Androgen-independent and Metastatic Tumor Growth in an Autochthonous Genetically Engineered Mouse Prostate Cancer Model by Sharon D. Morgenbesser; Rajashree P. McLaren; Brenda Richards; Mindy Zhang; Viatcheslav R. Akmaev; Scott F. Winter; Nora D. Mineva; Paula J. Kaplan‐Lefko; Barbara A. Foster; Brian P. Cook; Michael R. Dufault; Xiahong Cao; Clarence J. Wang; Beverly A. Teicher; Katherine W. Klinger; Norman M. Greenberg; Stephen L. Madden is a Medicine article available to read on EtoBox.

What is Identification of Genes Potentially Involved in the Acquisition of Androgen-independent and Metastatic Tumor Growth in an Autochthonous Genetically Engineered Mouse Prostate Cancer Model about?

## Abstract ## BACKGROUND A major focus of prostate cancer research has been to identify genes that are deregulated during tumor progression, potentially providing diagnostic markers and therapeutic targets. ## METHODS We have employed serial analysis of gene expression (SAGE) and microarray hybridization to identify alterations that occur during malignant transformation in the Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model. Many of these alterations were validated by real‐time PCR (rtPCR). ## RESULTS We identified several hundred mRNAs that were deregulated. Cluster analysis of microarray profiles with samples from various stages of the disease demonstrated that androgen‐independent (AI) primary tumors are similar to metastases; 180 transcripts have expression patterns suggesting an involvement in the genesis of late‐stage tumors, and our data support a role for phospholipase A2 group IIA in the acquisition of their highly aggressive characteristics. ## CONCLUSIONS Our analyses identified well‐characterized genes that were previously known to be involved in prostate cancer, validating our study, and also uncovered transcripts that had not previously been implicated

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Author

Sharon D. Morgenbesser; Rajashree P. McLaren; Brenda Richards; Mindy Zhang; Viatcheslav R. Akmaev; Scott F. Winter; Nora D. Mineva; Paula J. Kaplan‐Lefko; Barbara A. Foster; Brian P. Cook; Michael R. Dufault; Xiahong Cao; Clarence J. Wang; Beverly A. Teicher; Katherine W. Klinger; Norman M. Greenberg; Stephen L. Madden

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2006

Language

EN

Field

Medicine (Health Sciences)