Can I read Synthesis and Antidepressant Activity of Some 1,3,5-Triphenyl-2-pyrazolines and 3-(2′′-Hydroxy Naphthalen-1′′-yl)-1,5-diphenyl-2-pyrazolines on EtoBox?

Synthesis and Antidepressant Activity of Some 1,3,5-Triphenyl-2-pyrazolines and 3-(2′′-Hydroxy Naphthalen-1′′-yl)-1,5-diphenyl-2-pyrazolines by Y. Rajendra Prasad; A. Lakshmana Rao; L. Prasoona; K. Murali; P. Ravi Kumar is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Synthesis and Antidepressant Activity of Some 1,3,5-Triphenyl-2-pyrazolines and 3-(2′′-Hydroxy Naphthalen-1′′-yl)-1,5-diphenyl-2-pyrazolines about?

Five new 1,3,5-triphenyl-2-pyrazolines were synthesised by reacting 1,3-diphenyl-2-propene-1-one with phenyl hydrazine hydrochloride and another five new 3-(2 00 -hydroxy naphthalen-1 00 -yl)-1,5-diphenyl-2-pyrazolines were synthesised by reacting 1-(2 0hydroxynaphthyl)-3-phenyl-2-propene-1-one with phenyl hydrazine hydrochloride. The structures of the compounds were proved by means of their IR, 1 H NMR spectroscopic data, and microanalyses. The antidepressant activity of these compounds was evaluated by the ÔPorsolt behavioural despair testÕ on Swiss-Webster mice.1-Phenyl-3-(2 00 -hydroxyphenyl)-5-(4 0 -dimethylaminophenyl)-2-pyrazoline, 5-(4 0 -dimethylaminophenyl)-1,3-diphenyl-2-pyrazoline, 1-phenyl-3-(2 00 -hydroxynaphthalen-1 00 -yl)-5-(3 0 ,4 0 ,5 0 -trimethoxyphenyl)-2-pyrazoline, 1-phenyl-3-(4 00 -methylphenyl)-5-(4 0 -dimethylaminophenyl)-2-pyrazoline and 1-phenyl-3-(4 00 -bromophenyl)-5-(4 0dimethyl amino phenyl)-2-pyrazoline reduced immobility times 25.63-59.25% at 100 mg/kg dose level. In addition, it was found that the compounds possessing electron-releasing groups such as dimethyl amino, methoxy and hydroxyl substituents, on both the aromatic rings at positions 3 and

Who reads Synthesis and Antidepressant Activity of Some 1,3,5-Triphenyl-2-pyrazolines and 3-(2′′-Hydroxy Naphthalen-1′′-yl)-1,5-diphenyl-2-pyrazolines?

Author

Y. Rajendra Prasad; A. Lakshmana Rao; L. Prasoona; K. Murali; P. Ravi Kumar

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)