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Hemodynamic changes after ligation of a major branch of the portal vein in rats: Comparison with rats with portal vein constriction by Soonho Um; Osamu Nishida; Masaki Tokubayashi; Fumiko Kimura; Yukinobu Takimoto; Hideyuki Yoshioka; Ryoichi Inque; Toru Kita is a Medicine article available to read on EtoBox.
What is Hemodynamic changes after ligation of a major branch of the portal vein in rats: Comparison with rats with portal vein constriction about?
In chronic portal-hypertensive rat models, such as portal vein constriction or cirrhosis, the portal blood flow that effectively perfuses the hepatocytes is substantially reduced because of anatomical or functional shunts. It is possible therefore that a feedback mechanism from the liver to the splanchnic bed is responsible for the splanchnic hyperemia observed in chronic portal hypertension. To investigate the possible role of such a feedback mechanism, we examined the chronological changes in both portal and systemic hemodynamics in rats after ligation of a major branch of the portal vein that supplies about 80% of the liver circulation. Rats submitted to sham surgery and portal vein-constrkted rats were also studied. Blood flow and portal-systemic shunting were measured by radioactive microsphere techniques. For 7 days after portalbranch ligation, transient portal hypertension resulted from an elevated portal resistance. However, no s i m c a n t changes in portal venous inflow or splanchnic arteriolar residmnce were found in the portal branch-ligated rats, whereas in the portal vein-constricted rats significant hyperdynamic changes in these parameters were noted. On the other h
Who reads Hemodynamic changes after ligation of a major branch of the portal vein in rats: Comparison with rats with portal vein constriction?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Soonho Um; Osamu Nishida; Masaki Tokubayashi; Fumiko Kimura; Yukinobu Takimoto; Hideyuki Yoshioka; Ryoichi Inque; Toru Kita
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)