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282 Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE): a Proof of Concept Randomized Clinical Trial by Kwon, Sophia (author);Lam, Rachel (author);Crowley, George (author);Zeig-Owens, Rachel (author);Schwartz, Theresa (author);Colbeth, Hilary (author);Lou Pompeii, Mary (author);St-Jules, David E. (author);Prezant, David J. (author);Sevick, Mary Ann (author);Liu, Mengling (author);Nolan, Anna (author) is a Medicine article available to read on EtoBox.

What is 282 Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE): a Proof of Concept Randomized Clinical Trial about?

OBJECTIVES/GOALS: Particulate matter (PM) and metabolic syndrome (MetSyn) increase risk of World Trade Center-Lung Injury (WTC-LI). Mediterranean-type diets have also been found to improve lung function. Fire Department of New York 1st-responders with a high PM exposure at WTC and MetSyn may have improved lung function after a Mediterranean dietary intervention. METHODS/STUDY POPULATION: Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) randomized clinical trial (RCT) assessed our hypothesis that a low-calorie Mediterranean (LoCalMed) intervention targeting clinically relevant disease modifiers will improve metabolic risk, subclinical indicators of cardiopulmonary disease, quality of life, and lung function in firefighters with WTC-LI. Primary-outcome targeted a LoCalMed loss of BMI(≥1kg/m2). Secondary-outcomes included lung function, quality of life, and cardiovascular health. Male firefighters with WTC-LI and a BMI>27kg/m2 were randomized to: 1. LoCalMed (n=46); or 2. Usual Care (UC; n=43). Clinicaltrials.gov:NCT03581006. RESULTS/ANTICIPATED RESULTS: LoCalMed’s estimated efficacy on BMI reduction crossed the pre-specified significance boundary on interi

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Author

Kwon, Sophia (author);Lam, Rachel (author);Crowley, George (author);Zeig-Owens, Rachel (author);Schwartz, Theresa (author);Colbeth, Hilary (author);Lou Pompeii, Mary (author);St-Jules, David E. (author);Prezant, David J. (author);Sevick, Mary Ann (author);Liu, Mengling (author);Nolan, Anna (author)

Publisher

Cambridge University Press (CUP)

Published

2023

Language

EN

Field

Medicine (Health Sciences)