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Studies on the Non‐covalent Complexes Between Oleanolic Acid and Cyclodextrins Using Electrospray Ionization Tandem Mass Spectrometry by Mingquan Guo; Suoqing Zhang; Fengrui Song; Daowu Wang; Zhiqiang Liu; Shuying Liu is a Chemistry article available to read on EtoBox.

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## Abstract Non‐covalent inclusion complexes formed between an anti‐inflammatory drug, oleanolic acid (OA), and α‐, β‐ and γ‐cyclodextrins (CDs) were investigated by means of solubility studies and electrospray ionization tandem mass spectrometry (ESI‐MS^__n__^). The order of calculated association constants (__K__~1 : 1~) of complexes between OA and different CDs in solution is in good agreement with the order of their relative peak intensities and the relative CID energies of the complexes under the same ESI‐MS^__n__^ conditions. These results indicate a direct correlation between the behaviors of solution‐ and gas‐phase complexes. ESI‐MS can thus be used to evaluate solution‐phase non‐covalent complexes successfully. The experimental results show that the most stable 1 : 1 inclusion complexes between three CDs and OA can be formed, but 2 : 1 CD–OA complexes can be formed with β‐ and γ‐CDs. Multi‐component complexes of α‐CD–OA–β‐CD (1 : 1 : 1), α‐CD–OA–γ‐CD (1 : 1 : 1) and β‐CD–OA–γ‐CD (1 : 1 : 1) were found in equimolar CD mixtures with excess OA. The formation of 2 : 1 and multi‐component 1 : 1 : 1 non‐covalent CD–OA complexes indicates that β‐ and γ‐CD are able to form sandwic

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Author

Mingquan Guo; Suoqing Zhang; Fengrui Song; Daowu Wang; Zhiqiang Liu; Shuying Liu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley-Liss Inc; John Wiley & Sons Inc.; Wiley; Heyden And Son (ISSN 1076-5174)

Published

2003

Language

EN

Field

Chemistry (Physical Sciences)