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Macrophage Inflammatory Protein-2, Neutrophil Recruitment and Bacterial Persistence in an Experimental Mouse Model of Urinary Tract Infection by Rahul Mittal; Sanjay Chhibber; Saroj Sharma; Kusum Harjai is a Medicine article available to read on EtoBox.

What is Macrophage Inflammatory Protein-2, Neutrophil Recruitment and Bacterial Persistence in an Experimental Mouse Model of Urinary Tract Infection about?

This study analyzed macrophage inflammatory protein-2 (MIP-2) production and neutrophil recruitment in urinary tract in response to Pseudomonas aeruginosa in an ascending model of urinary tract infection (UTI) in mice. Both planktonic and biofilm cells of P. aeruginosa were used for inducing UTI in mice. MIP-2 levels determined in urine, bladder and kidney showed maximum MIP-2 production 6 h postinfection, which correlated with neutrophil recruitment. Biofilm cells showed significantly more MIP-2 production and neutrophil recruitment. However, no correlation between bacterial numbers and neutrophil recruitment was observed in urine and kidney tissue. The role of MIP-2 and neutrophils in relation to the persistence of P. aeruginosa in the urinary tract of mice is discussed.

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Author

Rahul Mittal; Sanjay Chhibber; Saroj Sharma; Kusum Harjai

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)

Published

2004

Language

EN

Field

Medicine (Life Sciences)