Opening book details…
Can I read Iron Deficiency and Its Epigenetic Effects on Iron Homeostasis on EtoBox?
Iron Deficiency and Its Epigenetic Effects on Iron Homeostasis by Bashar Farida; Kasimu G. Ibrahim; Bilyaminu Abubakar; Ibrahim Malami; Muhammad B. Bello; Murtala B. Abubakar; Abdullahi Y. Abbas; Mustapha U. Imam is a Environmental Science article available to read on EtoBox.
What is Iron Deficiency and Its Epigenetic Effects on Iron Homeostasis about?
Iron deficiency is a common micronutrient deficiency associated with metabolic changes in the levels of iron regulatory proteins, hepcidin and ferroportin. Studies have associated dysregulation of iron homeostasis to other secondary and life-threatening diseases including anaemia, neurodegeneration and metabolic diseases. Iron deficiency plays a critical role in epigenetic regulation by affecting the Fe2+/α-ketoglutarate-dependent demethylating enzymes, Ten Eleven Translocase 1–3 (TET 1–3) and Jumonji-C (JmjC) histone demethylase, which are involved in epigenetic erasure of the methylation marks on both DNA and histone tails, respectively. In this review, studies involving epigenetic effects of iron deficiency associated with dysregulation of TET 1–3 and JmjC histone demethylase enzyme activities on hepcidin/ferroportin axis are discussed.
Who reads Iron Deficiency and Its Epigenetic Effects on Iron Homeostasis?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Bashar Farida; Kasimu G. Ibrahim; Bilyaminu Abubakar; Ibrahim Malami; Muhammad B. Bello; Murtala B. Abubakar; Abdullahi Y. Abbas; Mustapha U. Imam
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)