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Severity of Iron Overload in Hemochromatosis: Effect of Volunteer Blood Donation Before Diagnosis by James C. Barton; Benjamin L. Preston; Sharon M. McDonnell; Barry E. Rothenberg is a Medicine article available to read on EtoBox.

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## Background: An effort was made to determine if volunteer blood donation before diagnosis decreases the severity of iron overload at diagnosis in persons with hemochromatosis. ## Study design and methods: A study was performed in 1089 persons in the united states with hemochromatosis who responded to a convenience sample survey and in 124 c282y/c282y hemochromatosis probands diagnosed during routine medical care. ## Results: Less than half of questionnaire respondents (46.2%) and probands (35.5%) reported that they had been volunteer blood donors; 5.4 percent and 4.0 percent, respectively, had donated >20 units of blood. in either subject group, there were no significant differences according to age in the mean numbers of units that needed to be removed by therapeutic phlebotomy to induce iron depletion in subgroups of men and women, respectively. similarly, there was no significant correlation of units of voluntary blood donation or of therapeutic phlebotomy index (= therapeutic phlebotomy units/age in years) with the number of therapeutic phlebotomy units needed to induce iron depletion. when questionnaire respondents were stratified by sex, there was no significant correlation

Who reads Severity of Iron Overload in Hemochromatosis: Effect of Volunteer Blood Donation Before Diagnosis?

Author

James C. Barton; Benjamin L. Preston; Sharon M. McDonnell; Barry E. Rothenberg

Publisher

Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)

Published

2001

Language

EN

Field

Medicine (Health Sciences)