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Can I read Electron-microscopic examination of Rickettsia tsutsugamushi-infected human liver on EtoBox?
Electron-microscopic examination of Rickettsia tsutsugamushi-infected human liver by Emsri Pongponratn; Yaowapa Maneerat; Urai Chaisri; Polrat Wilairatana; Benjanee Punpoowong; Parnpen Viriyavejakul; Mario Riganti is a Medicine article available to read on EtoBox.
What is Electron-microscopic examination of Rickettsia tsutsugamushi-infected human liver about?
**Summary**A 33 year‐old Thai woman was diagnosed with scrub typhus infection according to clinical symptoms, eschar lesions compatible with the disease, and specific antibody to __Rickettsia tsutsugamushi__ detected by indirect immunoperoxidase. Percutaneous transhepatic needle biopsies were taken before and 7 days after treatment with tetracycline to study the pathology of the liver. The liver tissue was evaluated by light microscopy, using H & E and Pinkerton's stains, and by transmission electron microscopy (TEM). Before treatment it showed reactive hepatitis. __Rickettsia__ organisms within the hepatocytes and sinusoids detected by Pinkerton's stain appeared as tiny bright‐red organisms. By TEM, the rod‐shaped double‐membrane __Rickettsiae__ appeared intact in the cytoplasm of Kupffer's cells and hepatocytes. After tetracycline treatment, moderate levels of acidophilic and ballooning liver cells were observed. The degree of cytoplasmic organelle damage varied, including fatty metamorphosis, depletion of glycogen granules, loss of the mitochondrial cristae, dilatation of endoplasmic reticulum and cytoplasmic vacuolation. __Rickettsia__ organisms cannot be visualized by Pinkerto
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- Author
- Emsri Pongponratn; Yaowapa Maneerat; Urai Chaisri; Polrat Wilairatana; Benjanee Punpoowong; Parnpen Viriyavejakul; Mario Riganti
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; ScienceOpen (ISSN 1360-2276)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)