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Can I read High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer on EtoBox?
High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer by Danijel Sikic; Markus Eckstein; Veronika Weyerer; Jennifer Kubon; Johannes Breyer; Florian Roghmann; Frank Kunath; Bastian Keck; Philipp Erben; Arndt Hartmann; Ralph M. Wirtz; Bernd Wullich; Helge Taubert; Sven Wach is a Medicine article available to read on EtoBox.
What is High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer about?
## Introduction: Molecular markers associated with breast cancer are assumed to be associated with outcome in non-muscle-invasive bladder cancer (nmibc). ## Materials and methods: We retrospectively investigated the association of the mrna expression of estrogen receptor 1 (esr1) and 2 (esr2), progesterone receptor (pgr), mki67, and her2 (erbb2) with recurrence-free (rfs), cancer-specific (css), and overall survival (os) in 80 patients with stage t1 nmibc. ## Results: High expression of esr2 (p = 0.003), erbb2 (p < 0.001), and mki67 (p = 0.029) was associated with shorter rfs. only high erbb2 was an independent prognostic factor for reduced rfs (hr = 2.98; p = 0.009). when sub stratifying the cohort, high esr2 was associated with reduced rfs (p < 0.001), css (p = 0.037) and os (p = 0.006) in patients without instillation therapy. high esr2 was associated with reduced css (p = 0.018) and os (p = 0.029) in females and with shorter rfs in both sexes (males: p = 0.035; females: p = 0.010). patients with high erbb2 showed reduced css (p = 0.011) and os (p = 0.042) in females and reduced css (p = 0.012) in those without instillation, while rfs was significantly reduced irrespective of se
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- Author
- Danijel Sikic; Markus Eckstein; Veronika Weyerer; Jennifer Kubon; Johannes Breyer; Florian Roghmann; Frank Kunath; Bastian Keck; Philipp Erben; Arndt Hartmann; Ralph M. Wirtz; Bernd Wullich; Helge Taubert; Sven Wach
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)