Can I read Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression on EtoBox?

Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression by Maria L. Barreiro Arcos; Helena A. Sterle; Maria A. Paulazo; Eduardo Valli; Alicia J. Klecha; Blanca Isse; Claudia G. Pellizas; Ricardo N. Farias; Graciela A. Cremaschi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression about?

Thyroid hormones (THs) exert a broad range of actions on development, growth, and cell differentiation by both genomic and nongenomic mechanisms. THs regulate lymphocyte function, but the participation of nongenomic actions is still unknown. Here the contribution of both genomic and nongenomic effects on TH-induced division of T cells was studied by using free and noncell permeable THs coupled to agarose (TH-ag). THs-ag led to cell division, but to a lesser extent than free hormones. THs induced nongenomically the rapid translocation of protein kinase C (PKC) z isoform to cell membranes, extracellular-signal-regulated kinases (ERK1/2) phosphorylation and nuclear factor-kB (NF-kB) activation. The signaling cascade include sphingomielinases acting up-stream the activation of PKCz isoform, while ERK and NF-kB are activated downstream this PKC isoenzyme. Both free and THs-ag increased the protein and mRNA levels of TH nuclear receptor TRa1, while only free hormones incremented the inducible NOS gene and protein levels as well as a calcium independent NOS activity. Both effects were blunted by PKCz inhibition. These results indicate that THs, by triggering a nongenomic signaling cascade

Who reads Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression?

Author

Maria L. Barreiro Arcos; Helena A. Sterle; Maria A. Paulazo; Eduardo Valli; Alicia J. Klecha; Blanca Isse; Claudia G. Pellizas; Ricardo N. Farias; Graciela A. Cremaschi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)