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Opportunistic Coeliac Disease Screening in Undifferentiated Presentations to Paediatric Acute Care by Karrnan Pathmanandavel; Melanie Wong; Emma Williams; Michael Stormon; Rebecca Nogajski; Andrew Williams is a Medicine article available to read on EtoBox.

What is Opportunistic Coeliac Disease Screening in Undifferentiated Presentations to Paediatric Acute Care about?

Aim: Coeliac disease (CD) can remain undiagnosed due to absent/atypical symptoms. We evaluated screening for CD in undifferentiated paediatric patients in the emergency department (ED). Methods: Subjects were all patients presenting to a children's hospital ED during the study period who had blood taken. Plasma remaining after routine care was tested for tissue transglutaminase IgA (tTG IgA) and deamidated gliadin IgG (DGP IgG) antibodies. Patients with positive results were counselled and offered confirmatory testing, then gastroenterology review if warranted. Results: An initial positive result for either DGP IgG or tTG IgA was found in 4.2% (44/1055). There was a normalisation of 76% (19/25) of positive DGP IgG and 44% (4/9) of tTG IgA results on repeat testing, which was not available in 27% (12/44). The prevalence of biopsy-confirmed CD was 0.7% (7/1055), including two new diagnoses and five subjects with known CD. Three likely cases could not be confirmed. All confirmed and likely cases were >10 years old. In children >10 years old, the prevalence of either biopsy-confirmed or likely CD was 3.3% (10/302). A family history of CD, growth concerns, recurrent abdominal pain and l

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Author

Karrnan Pathmanandavel; Melanie Wong; Emma Williams; Michael Stormon; Rebecca Nogajski; Andrew Williams

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)