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Comparison of Baseline Laboratory Findings of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis and Multisystem Inflammatory Syndrome in Children by Fatma Aydın; Elif Çelikel; Zahide Ekici Tekin; Serkan Coşkun; Müge Sezer; Cüneyt Karagöl; Melike Mehveş Kaplan; Nilüfer Tekgöz; Tuba Kurt; Serhan Özcan; Ahmet Vedat Kavurt; Aslınur Özkaya Parlakay; Banu Çelikel Acar is a Medicine article available to read on EtoBox.

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## Abstract ## Aims Recently, multisystem inflammatory syndrome in children (MIS‐C) has been recognized in association with coronavirus disease 2019 as a cytokine storm syndrome. MIS‐C presents with symptoms similar to Kawasaki disease and macrophage activation syndrome (MAS). We aimed to better understand this cytokine storm syndrome by comparing the initial laboratory findings of MIS‐C and MAS. ## Methods Patients who were diagnosed with MAS due to systemic juvenile idiopathic arthritis in our clinic between March 2002 and November 2020 and with MIS‐C between 20 September and 20 October 2020 were enrolled into the study. The medical files of all patients were reviewed retrospectively. ## Results A total of 13 MAS (9 boys, 4 girls) and 26 MIS‐C (16 boys,10 girls) patients were included in the study. Hemoglobin, absolute neutrophil and lymphocyte counts, C‐reactive protein (CRP), ferritin, fibrinogen and lactate dehydrogenase (LDH) levels showed significant differences between the two groups (P < 0.05). Patients with MAS had lower hemoglobin (10.10 g/dL) and fibrinogen (2.72 g/dL), but higher ferritin (17 863 mg/dL) and LDH (890.61 U/L) at the time of diagnosis. Patients with MIS‐C

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Author

Fatma Aydın; Elif Çelikel; Zahide Ekici Tekin; Serkan Coşkun; Müge Sezer; Cüneyt Karagöl; Melike Mehveş Kaplan; Nilüfer Tekgöz; Tuba Kurt; Serhan Özcan; Ahmet Vedat Kavurt; Aslınur Özkaya Parlakay; Banu Çelikel Acar

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)