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HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib by Eric Wehrenberg-Klee; Nicoleta Sinevici; Sarah Nesti; Taylor Kalomeris; Emily Austin; Benjamin Larimer; Umar Mahmood is a Medicine article available to read on EtoBox.
What is HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib about?
## Purpose: Standard therapy for her2+ breast cancers includes her2 inhibition. while her2 inhibitors have significantly improved therapeutic outcomes, many patients remain resistant to therapy. an important intrinsic resistance mechanism to her2 inhibition in some breast cancers is dynamic upregulation of her3. increase in her3 expression that occurs in response to her2 inhibition allows for continued growth signaling through her2/her3 heterodimers, promoting tumor escape. we hypothesized that a non-invasive method to image changes in her3 expression would be valuable to identify those breast cancers that dynamically upregulate her3 in response to her2 inhibition. we further hypothesized that this imaging method could identify those tumors that would benefit by additional her3 knockdown. ## Procedures: In a panel of her2+ breast cancer cell lines treated with the her2 inhibitor lapatinib, we evaluate changes in her3 expression and viability. mouse her2+ breast cancer models treated with lapatinib were imaged with a peptide-based her3-specific pet imaging agent [ga]her3p1 to assess for dynamic changes in tumoral her3 expression and uptake confirmed by biodistribution. subsequently,
Who reads HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib?
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- Author
- Eric Wehrenberg-Klee; Nicoleta Sinevici; Sarah Nesti; Taylor Kalomeris; Emily Austin; Benjamin Larimer; Umar Mahmood
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)