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The influence of excess vitamin A on neural tube closure in the mouse embryo by Jan A. G. Geelen; Jan Langman; Joseph D. Lowdon is a Neuroscience article available to read on EtoBox.

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The effect of excess vitamin A on the closure of the neural tube in mouse embryos was examined with light microscopy, transmission and scanning electronmicroscopy. The embryos were treated with the vitamin just before closure of the brain vesicles and examined during the following 24 h, a period during which under normal conditions the brain completely closes. At 18--24 h after treatment the external features of the treated specimens began to differ from those of the controls. In the treated embryos the neural walls folded laterally and became widely separated, whereas those of the controls folded dorsomedially and fused in the midline. Histologically, the first difference between treated and control embryos was noted at two hours after treatment, when large intercellular spaces appeared between the neuroepithelial cells of the treated embryos. These spaces were mainly present between the apical ends of the wedge-shaped neuroepithelial cells. This accumulation of intercellular spaces interfered with the normal morphogenetic movement of the neural walls which remained convex instead of becoming concave. This convex bending resulted in non-closure of the neural tube. In addition to t

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Author

Jan A. G. Geelen; Jan Langman; Joseph D. Lowdon

Publisher

Springer; Springer-Verlag; Springer Verlag; J.F. Bergmann; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-2061)

Published

1980

Language

EN

Field

Neuroscience (Life Sciences)