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Experimental antibacterial therapy with puroindolines, lactoferrin and lysozyme in Listeria monocytogenes-infected mice by Daniela Palumbo; Marco Iannaccone; Amalia Porta; Rosanna Capparelli is a Medicine article available to read on EtoBox.

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Puroindoline A and puroindoline B from plant seeds, bovine lactoferrin and chicken eggs lysozyme are antimicrobial proteins of innate immune system that lyse invading organisms. We investigate their potential antibacterial activity against Listeria monocytogenes in a mouse model. Bacteria were isolated from various organs for 7 days after challenge. Livers displayed consistently higher bacterial count (up to 10 7 cfu/ g) than spleens, kidneys and brains. The efficacy of the AMPs was therefore established by measuring the infection level (cfu number) of these organs. Puroindoline A and puroindoline B (5 mg/mouse), lactoferrin and lysozyme (1.25 mg/mouse), intravenously injected individually, inhibited bacterial growth completely. Puroindoline A, puroindoline B and lactoferrin were effective when administered 24 h before infection; lysozyme was effective at the time of infection or 5 days after. Their combined use resulted in the enhancement of individual antibacterial activities. Complete inhibition of bacterial growth was observed using concurrently 0.059 mg/mouse of puroindoline A and 0.019 mg/mouse of puroindoline B, lactoferrin and lysozyme. Individual antimicrobial proteins red

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Author

Daniela Palumbo; Marco Iannaccone; Amalia Porta; Rosanna Capparelli

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)

Published

2010

Language

EN

Field

Medicine (Life Sciences)