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Cytochrome P450 by Karanpreet Singh Bhatia; Aarthi Nivasini Mahesh; Shruti Bhatt is a book available to read on EtoBox.

What is Cytochrome P450 about?

Metabolic enzymes are key mediators of the metabolic fate of a drug determining pharmacokinetic, pharmacodynamics, and therapeutic effect of the drug. Human Cytochrome P450 (CYP450) enzymes are essential for the metabolism of drugs and endogenous compounds. CYP enzymes mediated metabolism occurs in multiple sites, of which liver and intestine are the primary sites. CYP450 enzymes, distributed into four major families, metabolize over 70% of clinically approved drugs in humans. Drug metabolism is achieved through Phase-I reactions (oxidation, reduction hydrolysis, and hydroxylation), Phase II reactions (conjugation), or both. Drugs and chemicals serve as inducers or inhibitors of various isozymes. Besides, genes encoding CYP450 enzymes are highly variable, resulting in genetic polymorphisms that impact the therapeutic efficacy of drugs. This chapter summarizes the classes and functions of cytochrome P450 enzymes, biochemistry, polymorphism, and factors that contribute to interindividual variations in drug responses.

Author

Karanpreet Singh Bhatia; Aarthi Nivasini Mahesh; Shruti Bhatt

Publisher

Elsevier Science & Technology Books

Published

2024

Language

EN

ISBN

9780128243152

Subjects

Medical, Medicine